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- Title
Tratamento de úlceras venosas com fatores de crescimento: revisão sistemática e metanálise.
- Authors
Rezende de Carvalho, Magali; Andrade Silveira, Isabelle; Renaud Baptista de Oliveira, Beatriz Guitton
- Abstract
Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.
- Subjects
GROWTH factors; CINAHL database; CONFIDENCE intervals; EPIDERMAL growth factor; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDICAL information storage &; retrieval systems; LEG ulcers; MEDLINE; META-analysis; WOUND healing; SYSTEMATIC reviews; PLATELET-rich plasma; THERAPEUTICS
- Publication
Revista Brasileira de Enfermagem, 2019, Vol 72, Issue 1, p209
- ISSN
0034-7167
- Publication type
Article
- DOI
10.1590/0034-7167-2017-0865