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- Title
The correlation between children's status asthmatics and interstitial lung disease.
- Authors
HAN, X.-M.; CHENG, Y.-Y.; GONG, Y.-F.; JIANG, M.-M.
- Abstract
OBJECTIVE: Investigating the correlation between children's status asthmatics and interstitial lung disease (ILD). PATIENTS AND METHODS: We continuously selected 20 cases of children's status asthmatics combined with ILD (group A), 20 cases of pure status asthmatics (group B), 20 cases of pure ILD (group C) and 20 cases of healthy children (group D). We measured Th1/Th2 by flow cytometry as well as the level of expression of hs-CRP, IL-7 cytokines (TSLP), monocyte chemoattractant protein-1 (MCP-1) and anti-Jo-1 antibody by ELISA method. RESULTS: Th1 and Th1/Th2 of groups A and B were significantly lower than those of group C and D. Th2 was significantly (p<0.05) higher than that of groups C and D. The level of expression of hs-CRP, TSLP, MCP-1 and anti-Jo-1 antibody in the groups A and B were all significantly higher (p<0.05) than those of groups C and D. There were differences of the above index of the comparison between groups A and B, but no difference between groups C and D. CONCLUSIONS: Children's status asthmatics and ILD may correlate with the abnormal expression of Th1/Th2, hs-CRP, TSLP, MCP-1 and anti- Jo-1 antibody.
- Subjects
ASTHMA in children; INTERSTITIAL lung diseases in children; CHILDREN'S health; FLOW cytometry; INTERLEUKIN-7; MONOCYTE chemotactic factor; ENZYME-linked immunosorbent assay
- Publication
European Review for Medical & Pharmacological Sciences, 2016, Vol 20, Issue 22, p4761
- ISSN
1128-3602
- Publication type
Article