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- Title
Basal Release of ATP: An Autocrine- Paracrine Mechanism for Cell Regulation.
- Authors
Corriden, Ross; Insel, Paul A.
- Abstract
Cells release adenosine triphosphate (ATP), which activates plasma membrane- localized P2X and P2Y receptors and thereby modulates cellular function in an autocrine or paracrine manner. Release of ATP and the subsequent activation of P2 receptors help establish the basal level of activation (sometimes termed "the set point") for signal transduction pathways and regulate a wide array of responses that include tissue blood flow, ion transport, cell volume regulation, neuronal signaling, and host-pathogen interactions. Basal release and autocrine or paracrine responses to ATP are multifunctional and evolutionarily conserved, and they provide an economical means for the modulation of cell, tissue, and organismal biology.
- Publication
Science Signaling, 2010, Vol 3, Issue 104, p1
- ISSN
1945-0877
- Publication type
Article
- DOI
10.1126/scisignal.3104re1