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- Title
Apolipoprotein E among Korean Alzheimer's Disease Patients in Community-Dwelling and Hospitalized Elderly Samples.
- Authors
Kim, Jae-Min; Shin, Il-Seon; Yoon, Jin-Sang
- Abstract
This study evaluated the association of the apolipoprotein E ε4 allele (ε4) with Alzheimer's disease (AD) and investigated the relationships of ε4 with clinical characteristics of AD in both community-dwelling and hospitalized Korean elderly populations. The apolipoprotein E genotypes were compared between a group of 52 community-dwelling patients with AD (C-AD), a group of 52 hospitalized patients with AD (H-AD) and a group of 52 healthy controls matched to C-AD. Clinical characteristics and scores on several assessment scales were compared between C-AD and H-AD as well as between two subgroups within each AD group: those with ε4 and those without ε4. For H-AD, the assessment scales were administered again 6 months later, and the temporal course of AD was compared between the subgroups. The frequency of ε4 was significantly higher in both AD groups than in controls. Between C-AD and H-AD, no differences were found in ε4 frequency, while symptoms of dementia were significantly severer in H-AD than in C-AD. Within each AD group, no differences were observed in terms of clinical characteristics and scores on the assessment scales between the subgroups. Furthermore, the subgroups of H-AD showed no difference in the rate of progression. In conclusion, there was a significant association of ε4 with AD. However, no relationships were found between ε4 and clinical characteristics in either C-AD or H-AD. Furthermore, the rate of progression did not vary with respect to the presence or absence of ε4 in H-AD. The severer symptoms observed in the hospitalized sample than in those at large might be explained by factors other than the impact of ε4. Copyright © 2002 S. Karger AG, Basel
- Publication
Dementia & Geriatric Cognitive Disorders, 2002, Vol 13, Issue 3, p119
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000048643