The article provides an information that more than 85 medications are possibly interacting with grapefruit. It is mentioned that medications which interact with grapefruit are taken orally, have low to intermediate bioavailability, and are metabolized by cytochrome P450 3A4. It also states that grapefruit reduces the cytochrome P450 3A4 (CYP3A4) enzyme activity. Adverse effects of grapefruit including rhabdomyolysis, myelotoxicity, and respiratory depression are also mentioned.