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- Title
Increased Diet Quality is Associated with Long-Term Reduction of Abdominal and Pericardial Fat.
- Authors
Hennein, Rachel; Liu, Chunyu; McKeown, Nicola M; Hoffmann, Udo; Long, Michelle T; Levy, Daniel; Ma, Jiantao
- Abstract
<bold>Objective: </bold>This study examined the longitudinal associations between genetic risk, change in diet quality, and change in visceral adipose tissue (ΔVAT), abdominal subcutaneous adipose tissue (ΔSAT), and pericardial adipose tissue (ΔPAT).<bold>Methods: </bold>A total of 1,677 Framingham Heart Study participants who had ectopic fat depots measured using computed tomography were analyzed. Diet quality was quantified using a Mediterranean-style diet score (MDS) and genetic risk by depot-specific genetic risk scores (GRSs).<bold>Results: </bold>Per SD improvement in MDS, there was 50 cm3 (95% CI: 14-86; P = 0.007) less fat accumulation in VAT, 52 cm3 (95% CI: 12-92; P = 0.01) less fat accumulation in SAT, and 1.3 cm3 (95% CI: 0.1-2.4; P = 0.04) less fat accumulation in PAT. No association was observed between GRSs and ΔVAT or ΔSAT. Each 1-SD increase in the PAT GRS was associated with a 1.2-cm3 (95% CI: 0.1-2.3; P = 0.03) increase in ΔPAT. In participants with higher PAT GRS, those with ΔMDS ≥ 0 had a favorable change in PAT compared with the counterparts with ΔMDS < 0 (P = 0.008).<bold>Conclusions: </bold>Longitudinal improvements in diet quality are associated with less ectopic fat accumulation. This study suggests that diet quality may play a critical role in improving ectopic adiposity profiles.
- Publication
Obesity (19307381), 2019, Vol 27, Issue 3, pN.PAG
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22427