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- Title
Characterization of ultrasonically extracted flaxseed polysaccharide gum and assessing its lipid‐lowering potential in a rat model.
- Authors
Akhtar, Muhammad Nadeem; Khalil, Anees Ahmed; Bilal, Ahmed; Afzaal, Muhammad; Tufail, Tabussam; Saeed, Rabia; Siddique, Rabia; Nemat, Arash; Manzoor, Muhammad Faisal
- Abstract
Flaxseed polysaccharide gum (FPG) was extracted through the ultrasound‐assisted process using water as a solvent with a yield ranging from 8.05 ± 0.32% to 12.23 ± 0.45% by changing different extraction variables. The extracted FPG was analyzed for its functional groups and antioxidant potential. The maximum DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) free radical scavenging activity (≈100%) of FPG was noted at concentrations beyond ≈10 mg·ml−1. The maximum inhibition percentage through ABTS (2,2′‐azino‐bis 3‐ethylbenzothiazoline‐6‐sulfonic acid) (72.4% ± 1.9%) was noted at 40 mg·ml−1, which was observed to be less when compared to DPPH at the same concentration. The total antioxidant potential of the FPG solution at a concentration of 10 mg·ml−1 was equivalent to 461 mg ascorbic acid, which tends to increase with concentration at a much lower scope. The in vivo trial suggested that the least weight gain was noted in experimental groups G2 and Gh2. A significant reduction in total cholesterol was noticed in G1 (−14.14%) and G2 (−17.72%) and in Gh1 (−22.02%) and Gh2 (−34.68%) after 60 days of the trial compared to the baseline values. The maximum reduction in total triglyceride was observed in Gh2 (−25.06%) and Gh1 (−22.01%) after 60 days of the trial. It was an increasing trend in high‐density lipoprotein cholesterol (HDL‐c) in different experimental groups G2 (10.51%) than G1 (5.35%) and Gh2 (48.96%) and Gh1 (31.11%), respectively, after 60 days of study interval. Reduction of −5.05% and − 9.45% was observed in G1 and G2, while similar results were observed in Gh1 and Gh2. Conclusively, results suggested a possible protective role of FPG against hyperlipidemia.
- Subjects
POLYSACCHARIDES; HDL cholesterol; ANIMAL disease models; FLAXSEED; WEIGHT gain
- Publication
Food Science & Nutrition, 2023, Vol 11, Issue 1, p137
- ISSN
2048-7177
- Publication type
Article
- DOI
10.1002/fsn3.3045