We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High-risk age window for mortality in children with cystic fibrosis after lung transplantation.
- Authors
Hayes, Don; McCoy, Karen S.; Whitson, Bryan A.; Mansour, Heidi M.; Tobias, Joseph D.
- Abstract
LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality ( HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant ( HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.
- Subjects
CYSTIC fibrosis; LUNG transplantation; MEDICAL databases; CHILD mortality; SURVIVAL analysis (Biometry)
- Publication
Pediatric Transplantation, 2015, Vol 19, Issue 2, p206
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/petr.12401