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- Title
A new heterotropic vascularized model of total urinary bladder transplantation in a rat model.
- Authors
Jundziłł, Arkadiusz; Witmanowski, Henryk; Żary-Sikorska, Ewa; Adamowicz, Jan; Bodnar, Magdalena; Marszałek, Andrzej; Kloskowski, Tomasz; Męcińska-Jundziłł, Kaja; Gagat, Maciej; Siedlecka, Natalia; Drewa, Tomasz; Pokrywczyńska, Marta
- Abstract
This study developed a new procedure of urinary bladder transplantation on a rat model (n = 40). Heterotopic urinary bladder transplantation (n = 10) in the right groin vessels was performed. Direct urinary bladder examination, microangiography, histological analysis, and India ink injection were performed to evaluate the proposed method's functionality. Observation time was four weeks. One week after the procedure, the graft survival rate was 80%, two urinary bladders were lost due to anastomosis failure. The rest of the grafts survived two weeks without any complications. Lack of transitional epithelium or smooth muscle layer loss and lack of inflammatory process development were observed. This study was performed in order to obtain the necessary knowledge about urinary bladder transplantation. The proposed technique offers a new approach to the existing orthotropic models.
- Subjects
TRANSPLANTATION of organs, tissues, etc.; BLADDER examination; SURGICAL anastomosis; LABORATORY rats; INFLAMMATION
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-021-83128-w