We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Population pharmacokinetics of intravenous valproic acid in Korean patients.
- Authors
Park, H.-M.; Kang, S.-S.; Lee, Y.-B.; Shin, D.-J.; Kim, O.-N.; Lee, S.-B.; Yim, D.-S.
- Abstract
Summary Objective: To determine population-based pharmacokinetic parameters for intravenous valproic acid, and the factors influencing these parameters, in Korean adults. Methods: Valproic acid concentrations were obtained using a peak and trough sampling scheme for 102 Korean epileptic patients who were not taking concurrent antiepileptic medication. Three hundred and fifty-four serum concentrations were analysed according to a one-compartment model with a mixed effect modelling method (NONMEM Ver 5·0). The influence of body-weight (kg), height, daily valproic acid dose (mg/day), body mass index (kg/m2 ), sex, and age on volume of distribution (Vd) and clearance (CL) was assessed in the course of analysis. Results: Vd and CL of valproic acid increased with body-weight. No significant influence of the other screened covariates was observed. The final regression model was:&formmu0;&formmu1; Interindividual variabilities (coefficient of variation) for CL and Vd were 32 and 18%, respectively. Residual error including intraindividual variability was 26·7%. Conclusion: The current results may be used as a basic reference to optimize drug therapy with intravenous valproic acid. Further research on the paediatric population is necessary to confirm the non-linearity of the relation between body-weight and Vd.
- Subjects
VALPROIC acid; TREATMENT of epilepsy; PHARMACOKINETICS
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2002, Vol 27, Issue 6, p419
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1046/j.1365-2710.2002.00440.x