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- Title
Cellular sources of new pancreaticßcells and therapeutic implications for regenerative medicine.
- Authors
Halban, Philippe A.
- Abstract
Replacing missing insulin-producingßcells to treat diabetes is a major challenge for regenerative medicine. A better understanding ofß-cell embryogenesis and regeneration in adult life is needed to devise means to derive these specialized cells in sufficiently large numbers from stem or precursor cells. It is also critical to ensure that any surrogate or regeneratedßcells have perfectly regulated insulin production, which is essential for physiological glucose homeostasis.
- Subjects
HYPOGLYCEMIC agents; PANCREATIC secretions; PHYSIOLOGICAL control systems; ENDOCRINE diseases; CARBOHYDRATE intolerance; CELLS
- Publication
Nature Cell Biology, 2004, Vol 6, Issue 11, p1021
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1104-1021