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- Title
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
- Authors
Meller, Nahum; Irani-Tehrani, Mohammad; Kiosses, William B.; Del Pozo, Miguel A.; Schwartz, Martin A.
- Abstract
The Rho family GTPases Rac, Rho and Cdc42 are critical in regulating the actin-based cytoskeleton, cell migration, growth, survival and gene expression. These GTPases are activated by guanine nucleotide-exchange factors (GEFs). A biochemical search for Cdc42 activators led to the cloning of zizimin1, a new protein whose overexpression induces Cdc42 activation. Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42. CZH2-containing proteins constitute a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac. Together, the results suggest that CZH2 is a new GEF domain for the Rho family of proteins.
- Subjects
G proteins; MEMBRANE proteins; CYTOSKELETON
- Publication
Nature Cell Biology, 2002, Vol 4, Issue 9, p639
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb835