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- Title
Bringing SOD1 into the fold.
- Authors
Barmada, Sami; Finkbeiner, Steven
- Abstract
The article reports on a study which suggests that wild-type superoxide dismutase 1 (SOD1) from sporadic amyotrophic lateral sclerosis (ALS) tissues shows conformational changes similar to those seen in familial ALS. The study suggests that oxidized SOD1 shares important structural and toxic features with mSOD1. The findings of the study suggest that SOD1 changes the conformation of the protein such that it exhibits the same three-dimensional epitope as mSOD1.
- Subjects
SUPEROXIDE dismutase; AMYOTROPHIC lateral sclerosis; MANGANESE enzymes; OXIDOREDUCTASES; NEUROMUSCULAR diseases
- Publication
Nature Neuroscience, 2010, Vol 13, Issue 11, p1303
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn1110-1303