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- Title
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.
- Authors
Engblom, David; Saha, Sipra; Engstrom, Linda; Westman, Marie; Audoly, Lurent P.; Jakobsson, Per-Johan; Blomqvist, Anders
- Abstract
We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopolysaccharide, but their pyretic capacity in response to centrally administered PGE2 was intact. Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain.
- Subjects
FEBRILE seizures; PROSTAGLANDINS; BRAIN; CYTOKINES
- Publication
Nature Neuroscience, 2003, Vol 6, Issue 11, p1137
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn1137