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- Title
TGF-β1 content in atherosclerotic plaques, TGF-β1 serum concentrations and incident coronary events.
- Authors
Herder, Christian; Peeters, Wouter; Zierer, Astrid; de Kleijn, Dominique P. V.; Moll, Frans L.; Karakas, Mahir; Roden, Michael; Meisinger, Christa; Thorand, Barbara; Pasterkamp, Gerard; Koenig, Wolfgang
- Abstract
Eur J Clin Invest 2012; 42 (3): 329-337 Abstract Background We tested the hypothesis that high TGF-β1 content in atherosclerotic plaques and high TGF-β1 serum levels are associated with lower risk of coronary events in two independent prospective studies. Materials and methods In the prospective Athero-Express biobank study, total TGF-β1 plaque levels were measured in 632 atherosclerotic lesions from patients who underwent carotid endarterectomy. In a population-based case-cohort study within the Monitoring of trends and determinants in cardiovascular disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) Augsburg studies, baseline total TGF-β1 serum levels were measured in 333 individuals with and 1728 without incident coronary events. Results Patients with TGF-β1 content in their plaques above the study median did not have a lower risk of coronary events than patients with lower TGF-β1 levels [adjusted HR (95% CI) 1·46 (0·83-2·53); P = 0·16; mean follow-up 2·6 ± 0·7 years] in the Athero-Express biobank study. Cox proportional hazard models adjusting for age, sex, body mass index, metabolic factors, lifestyle factors and survey did not reveal a significant association between TGF-β1 serum levels and incident coronary events [HR (95% CI) for increasing TGF-β1 tertiles 1·0, 1·22 (0·88-1·68), 1·13 (0·82-1·57); P = 0·47; mean follow-up: 10·8 ± 4·6 years] in the MONICA/KORA Augsburg studies. Conclusion Our results indicate that high TGF-β1 content in human atherosclerotic plaques and high serum levels of TGF-β1 are not associated with reduced risk of coronary events.
- Subjects
SERUM; BLOOD plasma; ATHEROSCLEROTIC plaque; ARTERIAL stenosis; CARDIOVASCULAR diseases
- Publication
European Journal of Clinical Investigation, 2012, Vol 42, Issue 3, p329
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/j.1365-2362.2011.02587.x