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- Title
Iohexol contrast medium induces QT prolongation in amiodarone patients.
- Authors
Goernig, Matthias; Kirmeier, Thomas; Krack, Andreas; Hartog, Christiane S.; Figulla, Hans R.; Leder, Uwe
- Abstract
Amiodarone is widely used in ventricular tachyarrhythmias and atrial fibrillation, known to prolong QT-intervals. Concurrent administration of drugs prolonging QT- time can induce life-threatening ventricular tachyarrhythmia. QT-interval changes following use of Iohexol contrast-medium for coronarangiography were observed comparing 21 patients taking long-term amiodarone therapy with 21 controls not taking amiodarone or QT-prolonging drugs retrospectively. Concurrent use of Iohexol and amiodarone was associated with significant prolongation of QTc-interval (433, 95%CI: 419–448 ms vs. 480, 95%CI: 422–483 ms, P < 0.001) the day after coronarangiograpgy. 6/21 patients showed severe prolonged QTc-interval of >500 ms. Caution is advised until more is known about pro-arrhythmic effects of Iohexol.
- Subjects
AMIODARONE; TACHYARRHYTHMIAS; ATRIAL fibrillation; DRUG administration; ANGIOGRAPHY; THERAPEUTICS
- Publication
British Journal of Clinical Pharmacology, 2004, Vol 58, Issue 1, p96
- ISSN
0306-5251
- Publication type
Article
- DOI
10.1111/j.1365-2125.2004.02119.x