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- Title
High-dose remifentanil increases blood pressure and heart rate mediated by sympatho-activation in conscious rats.
- Authors
Shirasaka, Tetsuro; Yano, Takeshi; Kunitake, Takato; Tsuneyoshi, Isao
- Abstract
Purpose: The ultra-short-acting μ-opioid receptor agonist, remifentanil, is commonly used in clinical anesthesia; however, there are limited data about the hemodynamic effects of remifentanil itself without anesthetics. We investigated the effects of an ultra-short-acting μ-opioid receptor agonist, remifentanil, on cardiovascular and sympathetic function in conscious rats. Methods: The mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) were recorded during continuous intravenous (i.v.) infusion of remifentanil at a moderate-dose (0.25 and 0.5 μg/kg/min) and a high-dose (1.0 and 2.0 μg/kg/min) in conscious intact and sino-aortic denervated (SAD) rats. Baroreflex sensitivity was examined during remifentanil administration. Rats were administered saline or naloxone to assess the involvement of the μ-opioid receptor in the remifentanil-induced responses. Results: High-dose remifentanil induced biphasic changes in MAP and HR. Mediated by sympatho-activation, these parameters increased after briefly decreasing once. Subpressor-dose remifentanil enhanced baroreflex sensitivity. Changes in MAP, HR, and RSNA induced by remifentanil were inhibited by naloxone. Conclusions: High-dose remifentanil decreases MAP and HR transiently and increases these parameters mediated by the activation of sympathetic nerve activity in conscious rats.
- Subjects
BLOOD pressure; BLOOD; HEART beat; HEART conduction system; LABORATORY rats
- Publication
Journal of Anesthesia, 2013, Vol 27, Issue 3, p325
- ISSN
0913-8668
- Publication type
Article
- DOI
10.1007/s00540-012-1515-2