We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Facile Synthesis of Pyrrolidine-based Iminosugars as Potential Alpha-Glucosidase Inhibitors.
- Authors
BACHO, MUHAMAD ZULFAQAR; MOHAMMAT, MOHD FAZLI; SHAAMERI, ZURINA; WIBOWO, AGUSTONO; KAMARULZAMAN, FIRDAUS; HAMZAH, AHMAD SAZALI
- Abstract
A multifaceted approach comprising MCR (multicomponent reaction), amination and stereoselective reduction reactions was used to synthesize new pyrrolidine-based iminosugars. The key step of this strategy involves the contruction of a highly functionalised pyrroldine ring skeleton through MCR approach. Subsequently, amination and reduction reactions to the ring skeleton provide a quick access to new pyrrolidine-based imino sugars. The iminosugars were then tested against alpha glucosidase activity in which one compound (4-((4-methoxyphenyl)amino)pyrrolidin-3-ol), was found to be the most potent at low dosage.
- Subjects
ALPHA-glucosidases; IMINOSUGARS; GLUCOSIDASES; ASYMMETRIC synthesis; AMINATION; SKELETON
- Publication
Oriental Journal of Chemistry, 2020, Vol 36, Issue 2, p309
- ISSN
0970-020X
- Publication type
Article
- DOI
10.13005/ojc/360214