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- Title
Phenotypic Differences of CD103<sup>+</sup> Tissue-Resident Memory T Cells Associated with Various Cancers.
- Authors
Park, Hye Seon; Jeon, Yeonjin; Lee, Hyun; Lee, Heejae; Kim, Young-Ae; Park, In Ah; Bang, Won Seon; Lee, Miseon; Cho, Young Jin; Kim, Jihyeong; Gong, Gyungyub; Lee, Hee Jin
- Abstract
Background/Aims: The presence and clinical importance of tissue-resident memory T (TRM) cells have been recently described in association with various cancer types. However, the frequency and the traditional naïve–effector–memory phenotypic characteristics of TRM cells are largely unknown. Methods: We analyzed single-cell populations of colorectal cancer (CC, n = 18), stomach cancer (SC, n = 13), renal cell carcinoma (RCC, n = 19), and breast cancer (BC, n = 16) by dissociation of tumor tissue with collagenase/hyaluronidase. We investigated populations of naïve, effector, and memory T and TRM cells by flow cytometry. Results: Among CD8− cells, CC was associated with a significantly higher proportion of CD103+ T cells than other tumor types (p < 0.001). Among CD8+ cells, CC and SC were associated with higher CD103+ T-cell proportions than RCC and BC (p < 0.001). Significantly more CD8+ than CD8− cells expressed CD103 (p < 0.001). In association with SC, RCC, and BC, CD8+ T cells had a similar T-cell phenotype composition pattern: fewer effector T cells and more memory-type T cells among CD103+ cells compared with CD103− cells (p < 0.05). Tumors with higher proportion of CD103+ cells had no specific clinicopathologic characteristics than those with lower proportion of CD103+ cells. Conclusion: TRM cell abundance and phenotypes varied among CC, SC, RCC, and BC. Further studies regarding the functional differences of TRM associated with various tumors are warranted.
- Publication
Pathobiology, 2022, Vol 89, Issue 2, p116
- ISSN
1015-2008
- Publication type
Article
- DOI
10.1159/000518972