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- Title
Hypertension, Tachycardia, and Reversible Cardiomyopathy Temporally Associated with Milnacipran Use.
- Authors
Forman, Mervyn B.; Sutej, Paul G.; Jackson, Edwin K.
- Abstract
Elevated catecholamine levels are a well-recognized cause of various types of cardiomyopathy. Causes of catecholamine elevation include tumors, toxins, drugs, emotional stress, and sepsis. Milnacipran is a dual and equipotent inhibitor of norepinephrine and serotonin uptake. It is frequently prescribed as therapy for fibromyalgia, and the drug has a good safety profile. Herein, we report the case of a 42-year-old woman with undefined connective-tissue disease and fibromyalgia who developed a severe and reversible cardiomyopathy while taking recommended doses of milnacipran. The cardiomyopathy was associated with a hyperadrenergic state manifested by tachycardia, hypertension, and elevated plasma catecholamine levels. The discontinuation of milnacipran and the initiation of anti-failure therapy resulted in complete resolution of the cardiomyopathy in 6 months. To our knowledge, this is the first report of milnacipran as a possible cause of catecholamineinduced cardiomyopathy.
- Subjects
TREATMENT of fibromyalgia; HYPERTENSION; THERAPEUTICS; TACHYCARDIA treatment; TREATMENT of cardiomyopathies
- Publication
Texas Heart Institute Journal, 2011, Vol 38, Issue 6, p714
- ISSN
1526-6702
- Publication type
Case Study