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- Title
A DESCRIPTIVE STUDY OF EFFECT OF MAGNESIUM SULFATE IN ATTENUATING ARTERIAL BLOOD PRESSURE IN ELECTIVE LAPAROSCOPIC SURGERIES.
- Authors
Sreenivasulu, Kattamanchi; Koushik, Kethireddy; Monika, Nagepalli; Annamalai, R.; Sunil, C.
- Abstract
Introduction: For many surgical diseases, laparoscopic surgery has become the conventional treatment. The physiological repercussions of pneumoperitoneum, on the other hand, are cause for concern. The formation of pneumoperitoneum with carbon dioxide (CO2) presents a unique haemodynamic problem for patient anaesthesia management. The increased intra-abdominal pressure caused by pneumoperitoneum, combined with the head-up tilt, causes changes in cardiovascular, respiratory, stress, and acid-base physiology. Pneumoperitoneum causes alterations in the cardiovascular system such as an increase in mean arterial pressure, a decrease in cardiac output, and an increase in systemic vascular resistance, which can lead to altered tissue perfusion. Materials and methods: In the haemodynamic changes, the most important outcome measure is systolic blood pressure. Thus, expecting a 15 mmHg difference in systolic blood pressure between the Intervention and Control groups, a 95% confidence interval, power 85% and population variance 500, the sample size calculated for each arm was 80. All adult male patients aged 18-50 years, American Society of Anaesthesiologists Grade I/II with informed written consent and Mallampati score of up to Class II undergoing elective laparoscopic abdominal surgery under general anaesthesia were included. Patients with systemic disorders, on calcium channel blockers and in whom the surgery could not be completed laparoscopically were excluded. Results: Two groups of 80 each were labelled as Group A (magnesium sulfate 50 mg/kg)- Intervention group and Group B (Normal Saline 50 mL)- Control group. The mean of patients' age, weight and height were calculated between the two groups and were tabulated as shown below. Thus, it was concluded on the basis of the p value that the distribution of age, weight and height among the two groups were comparable and these factors did not have any influence on outcome. Conclusion: In our study, we conclude that IV magnesium sulfate, when given before pneumoperitoneum attenuates arterial pressure increase during elective laparoscopic abdominal surgeries. This attenuation is apparently related to reductions in the release of catecholamine, vasopressin or both by magnesium sulfate. We also found that there is no adverse effect of magnesium like sedation or prolonged neuromuscular blockade at the dose we used.
- Subjects
BLOOD pressure; MAGNESIUM sulfate; LAPAROSCOPIC surgery; SYSTOLIC blood pressure; ELECTIVE surgery; VASCULAR resistance; ANIMAL sedation
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 4, p1204
- ISSN
0975-3583
- Publication type
Article