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- Title
HPA-Axis Activity and Nutritional Status Correlation in Individuals with Alcohol Use Disorder.
- Authors
Georgakouli, Kalliopi; Manthou, Eirini; Fatouros, Ioannis G.; Deli, Chariklia K.; Koutedakis, Yiannis; Theodorakis, Yannis; Jamurtas, Athanasios Z.
- Abstract
Impaired activity of the hypothalamic–pituitary–adrenal axis (HPA-axis) is evident in alcohol use disorder (AUD), and may be implicated in various nutritional and metabolic alterations often seen in individuals with this disorder. The present study examined a possible correlation between HPA-axis activity and nutritional status components in individuals with AUD. Fourteen AUD and fourteen non-AUD males participated; anthropometric and body composition measurements were made, and fasting blood samples were analysed for plasma adrenal corticotropic hormone (ACTH), catecholamines, cortisol and beta-endorphin. Nutrient intake was estimated via a three-day diet record. Waist circumference and waist-to-hip ratio were increased in the AUD group. Thiamine and folic intake were lower in AUD group, although only folic acid intake was insufficient in both AUD and non-AUD groups. Increased epinephrine and norepinephrine were also observed in AUD group compared to non-AUD group. No clear correlation between HPA-axis activity and nutritional status components was found. This study showed that nutrient intake, body composition, and HPA-axis activity were different among AUD and non-AUD individuals. More research on the correlation between nutritional status and HPA-axis activity in AUD individuals should be conducted.
- Subjects
RESEARCH; BODY composition; ALCOHOLISM; SUBSTANCE abuse; ANTHROPOMETRY; CATECHOLAMINES; ADRENALINE; NORADRENALINE; HYPOTHALAMIC-pituitary-adrenal axis; WAIST-hip ratio; WAIST circumference; STATISTICAL correlation; NUTRITIONAL status; HYDROCORTISONE; ENDORPHINS; DISEASE complications
- Publication
Nutrients, 2022, Vol 14, Issue 23, p4978
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14234978