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- Title
The Effect of Phototherapy on Apaptosisin Hyperbilirubinemic Preterm Neonates.
- Authors
Afifi, Moamedfarouk; Mohsen Abdel Hakeem, Abdel Hakeem Abdel; Abdel Naeemn, Emad ALam; Abdel Razic, Marwa Ibrahem
- Abstract
Objective: This study aimed to assess the impact of hyperbilirubinemia and Intensive phototherapy on apaptosis in peripheral blood of preterm infants. Patients and Method: The study was conducted on 18 preterm infants with non-hemolytic hyperbilirubinemia and 9 control healthy preterm infants. Apaptosismarkers (anti-apoptotic protein Bcl2, and pro-apoptotic protein BAX) was assessed using ELISA technique. Blood samples wereobtained at enrollment in all infants and after24 hours of exposure to intensive phototherapy in jaundiced infants. Result: Before phototherapy, no significant difference in the serum levels of bcl2 and Bax protein between jaundiced and non-jaundiced preterm infants (P = 0.570, p= 0.329 respectively), After phototherapy The serum levels of Bcl2 decrease while The serum levels of BAX increased significantly (P=0.003, p<0.001 respectively). Conclusion: Hyperbilirubinemia does not influence apaptosis whereas intensive phototherapy do in preterm infants with hyperbilirubinemia.
- Subjects
PHOTOTHERAPY; PREMATURE infants; NEWBORN infants; BAX protein; HYPERBILIRUBINEMIA
- Publication
Indian Journal of Public Health Research & Development, 2020, Vol 11, Issue 5, p703
- ISSN
0976-0245
- Publication type
Article