We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Thermosensitive In Situ Gel Based on Solid Dispersion for Rectal Delivery of Ibuprofen.
- Authors
Liu, Yangdan; Wang, Xin; Liu, Youping; Di, Xin
- Abstract
The objective of this study was to develop a thermosensitive in situ gel based on solid dispersions (SDs) for rectal delivery of ibuprofen (IBU). Thermosensitive (poloxamer 407) and mucoadhesive (hydroxypropylmethyl cellulose E5 and sodium alginate) polymers were used to prepare the in situ gel and the sol-gel transition temperature ( T ) and gel strength were optimized. The in vitro release performance and in vivo pharmacokinetic properties of the in situ gel after their rectal administration to rabbits were investigated. Compared with the solid suppository, the cumulative release of the IBU SDs loaded in situ gel was significantly increased. The in vivo pharmacokinetics indicated that in situ gel had a higher peak plasma concentration ( C ) and area under the curve (AUC) in plasma than the solid suppositories. Histopathology results showed that the IBU in situ gel given at a dose of 15 mg/kg did not produce any irritation. In conclusion, this study suggested that the in situ gel could be an effective rectal formulation for IBU.
- Publication
AAPS PharmSciTech, 2018, Vol 19, Issue 1, p338
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-017-0839-5