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- Title
Solid-State Stability Issues of Drugs in Transdermal Patch Formulations.
- Authors
Sharma, Purnendu; Panda, Apoorva; Pradhan, Adwait; Zhang, Jiaxiang; Thakkar, Ruchi; Whang, Chang-Hee; Repka, Michael; Murthy, S.
- Abstract
The transdermal patch formulation has many advantages, including noninvasiveness, an ability to bypass the first-pass metabolism, low dosage requirements, and prolonged drug delivery. However, the instability of solid-state drugs is one of the most critical problems observed in transdermal patch products. Therefore, a well-characterized approach for counteracting stability problems in solid-state drugs is crucial for improving the performance of transdermal patch products. This review provides insight into the solid-state stability of drugs associated with transdermal patch products and offers a comprehensive update on the various approaches being used for improving the stability of the active pharmaceutical ingredients currently being used.
- Publication
AAPS PharmSciTech, 2018, Vol 19, Issue 1, p27
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-017-0865-3