We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development and In Vitro/ In Vivo Evaluation of Etodolac Controlled Porosity Osmotic Pump Tablets.
- Authors
Abd-Elbary, Ahmed; Tadros, Mina; Alaa-Eldin, Ahmed
- Abstract
The aim of the current work was the design and evaluation of etodolac controlled porosity osmotic pump (CPOP) tablets exhibiting zero-order release kinetics. Variables influencing the design of (1) core tablets viz., (a) osmogent type (sodium chloride, potassium chloride, mannitol, and fructose) and (b) drug/osmogent ratio (1:0.25, 1:0.50, and 1:0.75), and (2) CPOP tablets viz., (a) coating solution composition, (b) weight gain percentage (1-5%, w/ w), and (c) pore former concentration (5%, 10%, and 20%, v/ v), were investigated. Statistical analysis and kinetic modeling of drug release data were estimated. Fructose-containing core tablets showed significantly ( P < 0.05) more retarded drug release rates. An inverse correlation was observed between drug/fructose ratio and drug release rate. Coating of the optimum core tablets (F4) with a mixture of cellulose acetate solution (3%, w/ v), diethyl phthalate, and polyethylene glycol 400 (85:10:5, v/ v, respectively) till a 4% w/ w weight gain enabled zero-order sustained drug delivery over 24 h. Scanning electron microscopy micrographs of coating membrane confirmed pore formation upon contact with dissolution medium. When compared to the commercial immediate-release Napilac® capsules, the optimum CPOP tablets (F4-34) provided enhanced bioavailability and extended duration of effective etodolac plasma concentration with minimum expected potential for side effects in healthy volunteers.
- Publication
AAPS PharmSciTech, 2011, Vol 12, Issue 2, p485
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-011-9608-z