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- Title
Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-κB activation.
- Authors
Shao, Hong Jun; Jeong, Jin Boo; Kim, Kui‐Jin; Lee, Seong‐Ho
- Abstract
BACKGROUND Hispidin, a polyphenol compound mainly derived from the valuable medicinal mushroom Phellinus species, has been found to possess distinct biological effects. However, the anti-inflammatory potential of hispidin still remains uncharacterized. RESULTS In this study, the effects of hispidin on activation of nuclear factor kappa B ( NF-κB) and the subsequent production of inducible nitric oxide synthase ( iNOS) were determined in the lipopolysaccharide ( LPS)-induced macrophage RAW 264.7 cells. Our data indicated that hispidin inhibits transcriptional activity of NF-κB in a dose-dependent manner. Hispidin also attenuated LPS-induced NF-κB nuclear translocation and associated inhibitor of kappa B ( IκB-α) degradation. Furthermore, hispidin deceased iNOS protein expression and the generation of reactive oxygen species ( ROS) in the LPS-induced cells, but did not affect phosphorylation of mitogen-activated protein kinases. CONCLUSION These findings suggest that hispidin exhibits anti-inflammatory activity through suppressing ROS mediated NF-κB pathway in mouse macrophage cells. © 2014 Society of Chemical Industry
- Subjects
ANTI-inflammatory agents; POLYPHENOLS; NF-kappa B; NITRIC-oxide synthases; LIPOPOLYSACCHARIDES; PHOSPHORYLATION
- Publication
Journal of the Science of Food & Agriculture, 2015, Vol 95, Issue 12, p2482
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.6978