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- Title
Primary dermal pleomorphic liposarcoma: utility of adipophilin and MDM2/ CDK4 immunostainings.
- Authors
Ramírez‐Bellver, Jose L.; López, Joaquín; Macías, Elena; Alegría‐Landa, Victoria; Gimeno, Ignacio; Pérez‐Plaza, Alejandra; Kutzner, Heinz; Requena, Luis
- Abstract
Liposarcoma, usually arises in deep soft tissues and pleomorphic liposarcoma (PL), is the rarest histopathologic variant. However, 15 cases of entirely dermal PL have been reported. We describe a case of a 79-year-old man who developed a rapidly growing nodule on his thorax. Excisional biopsy was performed and immunohistochemical studies were carried. The lesion was a well-circumscribed dermal nodule composed of multivacuolated pleomorphic lipoblasts and atypical mitotic figures. Neoplastic cells expressed CD10 and resulted negative S100 protein, Melan-A, MITF-1, AE1/ AE3, CD4, CD68 ( PGM1), retinoblastoma gene family protein, pericentrine and lysozyme. Adipophilin stain showed the lipid contents in the cytoplasm of the neoplastic cells. MDM2 and CDK4 resulted both negative. A diagnosis of primary dermal PL was made. This case shows the utility of adipophilin immunostaining to prove the lipid contents in neoplastic cells, which has the advantage of using formalin-fixed paraffin-embedded tissue and making needless frozen sections and ultrastructural studies to show these findings. Negative MDM2/ CDK4 staining in our case argues against the possibility of dedifferentiated liposarcoma and further supports the diagnosis of true PL.
- Subjects
LIPOSARCOMA; HISTOPATHOLOGY; GENE amplification; OLDER men; IMMUNOSTAINING; DISEASES in older people
- Publication
Journal of Cutaneous Pathology, 2017, Vol 44, Issue 3, p283
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.12850