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- Title
Expression of laminin-5 γ2 chain in cutaneous pseudocarcinomatous hyperplasia.
- Authors
dos Santos, Aline M.; Carneiro, Fabiana P.; Queiroz, Amadeu J. R.; Damasceno, Emanuel A. M.; de Castro, Tércia M. M. L.; de Amorim, Rivadávio F. B.; Takano, Gustavo H. S.; Junqueira, Maria I. M. B.; de Magalhães, Albino V.
- Abstract
Background: Since the use of laminin-5 as a marker of invasiveness has been proposed by several authors, our objective was to compare the expression of this protein in pseudocarcinomatous hyperplasia and squamous cell carcinoma (SCC). Methods: Sixty-four paraffin-embedded skin biopsy samples with diagnosis of epidermal hyperplasia (non-pseudocarcinomatous), pseudocarcinomatous hyperplasia, actinic keratosis/carcinoma in situ, microinvasive and frankly invasive SCC were obtained for immunohistochemical study. Results: Adjacent normal epithelium and epidermal hyperplasia (non-pseudocarcinomatous) showed no staining. In pseudocarcinomatous hyperplasia, laminin-5 was positive, at least focally, in 14 of 16 (87.5%) samples and was concentrated in peripheral cells of elongated rete pegs and in migrating cells in dermis. In samples of microinvasive carcinoma (n = 7), the expression was observed in all cases and was concentrated in the leading edge of the tumor. All cases (n = 21) of frankly invasive SCC showed cells expressing laminin-5, at least focally. Well-differentiated areas of the tumor presented a pattern of expression in peripheral cells of tumor nests while a diffuse pattern of expression was observed in less differentiated areas. Conclusion: We showed that cytoplasmic laminin-5 expression should not be used as a criterion of malignancy and is not useful in distinguishing pseudocarcinomatous hyperplasia from microinvasive and well-differentiated SCC. dos Santos AM, Carneiro FP, Queiroz AJR, Damasceno EAM, de Castro TMML, de Amorim RFB, Takano GHS, Junqueira MIMB, de Magalhães AV. Expression of laminin-5 γ2 chain in cutaneous pseudocarcinomatous hyperplasia.
- Subjects
HYPERPLASIA; SQUAMOUS cell carcinoma; CLINICAL pathology; CELLULAR pathology; BIOPSY
- Publication
Journal of Cutaneous Pathology, 2011, Vol 38, Issue 11, p871
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.2011.01780.x