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- Title
Cerebral and Renal Oxygen Saturation Are Not Compromised in the Presence of Retrograde Blood Flow in either the Ascending or Descending Aorta in Term or Near-Term Infants with Left-Sided Obstructive Lesions.
- Authors
van der Laan, Michelle E.; Mebius, Mirthe J.; Roofthooft, Marcus T.R.; Bos, arend F.; Berger, Rolf M.F.; Kooi, Elisabeth M.W.
- Abstract
Background: In infants with left-sided obstructive lesions (LSOL), the presence of retrograde blood flow in either the ascending or descending aorta may lead to diminished cerebral and renal blood flow, respectively. Objectives: Our aim was to compare cerebral and renal tissue oxygen saturation (rSO2 ) between infants with LSOL with antegrade and retrograde blood flow in the ascending aorta and with and without diastolic backflow in the descending aorta. Methods: Based on 2 echocardiograms, the study group was categorized according to the direction of blood flow in the ascending and descending aorta. We measured cerebral and renal rSO2 using near-infrared spectroscopy and calculated fractional tissue oxygen extraction (FTOE). Results: Nineteen in- fants with LSOL, admitted to the NICU between 0 and 28 days after birth, were included. Infants with antegrade blood flow ( n = 12) and infants with retrograde blood flow in the ascending aorta ( n = 7) had similar cerebral rSO2 and FTOE during both echocardiograms. Only during the first echocardiogram, infants with retrograde blood flow in the ascending aorta had lower renal FTOE (0.14 vs. 0.32, p = 0.04) and tended to have higher renal rSO2 (80 vs. 65%, p = 0.09). The presence of diastolic backflow in the descending aorta was not associated with cerebral or renal rSO2 and FTOE during the first ( n = 8) as well as the second echocardiogram ( n = 10). Conclusions: Retrograde blood flow in the ascending aorta was not associated with cerebral oxygenation, while diastolic backflow in the descending aorta was not associated with renal oxygenation in infants with LSOL.
- Subjects
OXYGEN in the body; AORTA; BLOOD flow
- Publication
Neonatology (16617800), 2017, Vol 112, Issue 3, p217
- ISSN
1661-7800
- Publication type
Article
- DOI
10.1159/000473870