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- Title
An Outbreak of Dengue Fever in St. Croix (US Virgin Islands), 2005.
- Authors
Mohammed, Hamish; Ramos, Mary; Armstrong, Julie; Muñoz-Jordán, Jorge; Arnold-Lewis, Kathleen O.; Ayala, Aurimar; Clark, Gary G.; Tull, Eugene S.; Beatty, Mark E.
- Abstract
Background: Periodic outbreaks of dengue fever occur in the United States Virgin Islands. In June 2005, an outbreak of dengue virus (DENV) serotype-2 with cases of dengue hemorrhagic fever (DHF) was detected in St. Croix, US Virgin Islands. The objective of this report is to describe this outbreak of DENV-2 and the findings of a case-control study examining risk factors for DHF. Methodology/Principal Findings: This is the largest dengue outbreak ever recorded in St. Croix, with 331 suspected dengue cases reported island-wide during 2005 (62.2 cases/10,000 population); 54% were hospitalized, 21% had at least one hemorrhagic manifestation, 28% had thrombocytopenia, 5% had DHF and 1 patient died. Eighty-nine laboratory-positive hospitalized patients were identified. Of these, there were 15 (17%) who met the WHO criteria for DHF (cases) and 74 (83%) who did not (controls). The only variable significantly associated with DHF on bivariate or multivariable analysis was age, with an adjusted odds ratio (95% confidence interval) of 1.033 (1.003,1.064). Conclusions/Significance: During this outbreak of DENV-2, a high proportion of cases developed DHF and increasing age was significantly associated with DHF.
- Subjects
SAINT Croix (United States Virgin Islands); VIRGIN Islands; DENGUE; DISEASE outbreaks; DENGUE hemorrhagic fever; SEROTYPES; FLAVIVIRUSES; ARENAVIRUS diseases; BLOOD platelet disorders; HOSPITAL patients
- Publication
PLoS ONE, 2010, Vol 5, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0013729