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- Title
Nerve growth factor: From discovery to development for human use: The evolution opens doors for the treatment of neurotrophic keratitis and beyond.
- Authors
Mantelli, Flavio
- Abstract
The cornea is the most densely innervated tissue of the body with an estimated 7000 nociceptors/mm2, making it 400 times more sensitive than skin.1 Sensory innervation of the cornea is derived from the first branch of the trigeminal nerve. Given the highly conserved homology between murine and human NGF,12 Dompe Farmaceutici sought to engineer a recombinant human protein of NGF (rhNGF), which could be safe and effective for human use. Potential future applications of rhNGF beyond neurotrophic keratitis (NK) The research and development team at Dompe is exploring potential future applications of rhNGF in ocular diseases beyond NK.
- Subjects
NERVE growth factor; CORNEAL dystrophies; KERATITIS; HUMAN evolution; SENSE organs; NOBEL Prize in Physiology or Medicine
- Publication
Optometry Times, 2023, Vol 15, Issue 5, p8
- ISSN
0890-7080
- Publication type
Article