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- Title
Synthesis, Crystal Structure, Cytotoxicity, and Mechanism of Action of Zn<sup>II</sup>, Mn<sup>II</sup>, and Fe<sup>III</sup> Complexes with 6-Hydroxyloxoisoaporphine.
- Authors
Qin, Qi‐Pin; Meng, Ting; Wei, Zu‐Zhuang; Zhang, Chuan‐Hui; Liu, Yan‐Cheng; Liang, Hong; Chen, Zhen‐Feng
- Abstract
Complexes [Zn(L)2(H2O)] ( 1), [Mn(L)2(CH3OH)2] ( 2), and [Fe(L)2(CH3OH)Cl] ( 3) (H-L = 6-hydroxyloxoisoaporphine) were synthesized and characterized. Complex 1 is a five-coordinate distorted tetragonal pyramid, whereas complexes 2 and 3 are six-coordinate distorted octahedral structures. Complexes 1- 3 exhibited selective cytotoxicity against MGC80-3, Hep-G2, BEL-7404, and T-24 cells, with IC50 values in the range of 8.19-15.98 µ m, and low cytotoxicity to HL-7702 cells. T-24 was the tumor cell most sensitive to complexes 1- 3. Complexes 1- 3 induced T-24 cell arrest in the G1 and G2/M phases, which led to the upregulation of p27, CDK2, p53, and p21, and downregulation of Cyclin E, Chk1, CDC25A, and Chk2. Complexes 1- 3 triggered apoptosis in T-24 cells by a mitochondrial-dysfunction pathway. The interaction of complexes 1- 3 with DNA occurs most likely by means of an intercalation and cleavage mode.
- Subjects
MANGANESE compounds; CHEMICAL synthesis; ZINC compounds synthesis; IRON compound synthesis; CRYSTALLOGRAPHY; ANTINEOPLASTIC agents; INORGANIC compounds; THERAPEUTICS
- Publication
European Journal of Inorganic Chemistry, 2017, Vol 2017, Issue 12, p1824
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201601030