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- Title
Fate of patients with nasopharyngeal cancer who developed distant metastasis as first failure after definitive radiation therapy.
- Authors
Chang, Ji Hyun; Ahn, Yong Chan; Park, Hyojung; Oh, Dongryul; Noh, Jae Myoung; Sun, Jong ‐ Mu; Ahn, Myung ‐ Ju; Park, Keunchil
- Abstract
Background No consensus has been reached on the optimal treatment for patients with nasopharyngeal cancer (NPC) who develop distant metastasis after initial radiation therapy (RT). Methods Two hundred eighty-two patients with NPC received curative RT (+/- chemotherapy). Forty-six patients (16.3%) who developed distant metastasis as first failure formed the study group for the current analysis. Results The median interval from initial RT until distant metastasis was 11.6 months. With a median follow-up of 30 months among survivors, overall survival (OS) rates at 2 and 5 years were 53.7% and 30.5%, respectively. On multivariate analyses, 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT for initial staging, RT plus chemotherapy as initial treatment, metastatic lesion number <6, disease-free interval >9 months, distant metastasis only to lungs, and treatment with curative intent after distant metastasis were predictive of significantly better OS. Conclusion Combined with FDG-PET/CT, an aggressive treatment approach using locoregional modalities might be beneficial to patients with NPC with favorable prognostic factors, even after distant metastasis. © 2015 Wiley Periodicals, Inc. Head Neck 38: E293-E299, 2016
- Subjects
NASOPHARYNX cancer; METASTASIS; CANCER radiotherapy research; CANCER chemotherapy; POSITRON emission tomography; CANCER treatment
- Publication
Head & Neck, 2016, Vol 38, pE293
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23988