We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Outcomes for hypopharyngeal carcinoma treated with organ-preservation therapy.
- Authors
Edson, Mark A.; Garden, Adam S.; Takiar, Vinita; Glisson, Bonnie S.; Fuller, Clifton D.; Gunn, Gary B.; Beadle, Beth M.; Morrison, William H.; Frank, Steven J.; Shah, Shalin J.; Tao, Randa; William, William N.; Weber, Randal S.; Rosenthal, David I.; Phan, Jack
- Abstract
Background This study assessed outcomes of patients with hypopharyngeal carcinoma treated with organ-preservation therapy utilizing intensity-modulated radiation therapy (IMRT). Methods The medical records of 98 patients treated with definitive IMRT +/- chemotherapy from 2001 to 2013 for nonmetastatic hypopharyngeal cancer were retrospectively reviewed. Results Patients were treated to doses of 66 to 72 Gy. Eighty-three patients (85%) received chemotherapy. With median follow-up of 35 months, 2-year overall survival (OS), locoregional control, progression-free survival (PFS), and laryngectomy-free survival rates were 74%, 77%, 67%, and 65%, respectively. Functional laryngeal preservation rate was 76% at 2 years. N3 disease correlated with worse OS ( p < .01). Concurrent chemotherapy correlated with improved locoregional control ( p = .03) and complete response to induction chemotherapy correlated with improved OS and PFS ( p = .02). Actuarial 2-year and 5-year grade 3 treatment toxicities were 17% and 21%, respectively. Conclusion Favorable disease outcomes and functional laryngeal preservation rates can be achieved with IMRT for patients with hypopharyngeal cancer. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2091-E2099, 2016
- Subjects
HYPOPHARYNGEAL cancer; INTENSITY modulated radiotherapy; CANCER chemotherapy; CANCER radiotherapy research; PROGRESSION-free survival; CANCER treatment
- Publication
Head & Neck, 2016, Vol 38, pE2091
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24387