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- Title
Cytoprotective constituent of hoveniae lignum on both hep G2 cells and rat primary hepatocytes.
- Authors
An, Ren-Bo; Park, Eun-Jeon; Jeong, Gil-Saeng; Sohn, Dong-Hwan; Kim, Youn-Chul
- Abstract
A phytochemical investigation of the EtOH extract of Hoveniae Lignum yielded four phenolic compounds, phloretin ( 1), 5-(4′-hydroxyphenyl)-γ-valerolactone ( 2), (-)-epiafzelechin ( 3), and maesopsin ( 4). Compound 1 was hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with an EC50 value of 37.55 ± 0.42 μM. Compound 1 (0.4-200 μM) also significantly reduced tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes as measured by the cellular leakage of lactate dehydrogenase and the level of aspartate transaminase.
- Publication
Archives of Pharmacal Research, 2007, Vol 30, Issue 6, p674
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02977626