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- Title
Fast neutron radiotherapy for primary mucosal melanomas of the head and neck.
- Authors
Liao, Jay J.; Parvathaneni, Upendra; Laramore, George E.; Thompson, John A.; Bhatia, Shailender; Futran, Neal D.; Bhrany, Amit D.; Hawes, Stephen E.; Ladra, Matthew
- Abstract
Background Primary head and neck mucosal melanomas (HNMMs) are rare tumors managed with surgery and/or radiotherapy and associated with poor outcomes. Given their radioresistance, high linear energy transfer radiotherapy with neutrons may improve local control. Methods We conducted a retrospective review of 14 patients with HNMM treated with neutrons at the University of Washington from 1990 to 2012. Five patients had T3 disease, 9 had T4 disease, 3 had regional nodal disease, and 4 had distant metastases at diagnosis. Primary sites were sinonasal ( n=10), lip ( n=2), and palate ( n=2). Ten patients had initial surgical resection/debulking. Results Nine patients had gross residual disease, 6 had complete response, and 3 had partial response. Local control was achieved in 79% until death or last follow-up, and 50% developed distant metastases. Kaplan-Meier 5-year local control was 66% and overall survival was 21%. Conclusion High rates of locoregional control were achieved with neutrons, despite the presence of gross disease. Survival was limited by early distant metastases. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1162-1167, 2014
- Subjects
NECK injuries; SHRUNKEN heads; HEAD injuries; MEDICAL radiology; RADIATION therapy equipment; PHYSIOLOGICAL therapeutics
- Publication
Head & Neck, 2014, Vol 36, Issue 8, p1162
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23428