We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lymph node ratio as an independent prognostic factor in oral squamous cell carcinoma.
- Authors
Ebrahimi, Ardalan; Clark, Jonathan R.; Zhang, Wan Jing; Elliott, Michel S.; Gao, Kan; Milross, Christopher G.; Shannon, Kerwin F.
- Abstract
Background We aimed to validate the lymph node ratio (LNR) as an independent prognostic factor in oral squamous cell carcinoma (OSCC) and compare its utility with the current nodal staging system. Methods We conducted a retrospective analysis of 313 patients with OSCC undergoing neck dissection. The LNR was adjusted by relevant covariates in a multivariable Cox regression model. Results LNR displaced conventional nodal staging and was shown to be an independent predictor of regional failure ( p = .020), disease-specific ( p = .003) and overall survival ( p = .001). Patients with an LNR of 2.5% to 7.5%, 7.5% to 20%, and >20% had 2.6, 3.7, and 4.4 times the risk of death from OSCC, respectively, when compared with patients with an LNR <2.5%. Conclusions The LNR is an independent prognostic factor in OSCC and may be used in conjunction with the current TNM staging to enable better risk stratification and selection for adjuvant therapy. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
- Subjects
LYMPH nodes; SQUAMOUS cell carcinoma; ORAL cancer; ADJUVANT treatment of cancer; RETROSPECTIVE studies
- Publication
Head & Neck, 2011, Vol 33, Issue 9, p1245
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21600