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- Title
Midtrimester abortion using vaginal misoprostol for women with three or more prior cesarean deliveries
- Authors
Fawzy, Muhammad; Abdel-Hady, El-Said
- Abstract
<bold>Objective: </bold>To evaluate the safety and efficacy of vaginal misoprostol for second-trimester abortion in women with 3 or more prior cesarean deliveries.<bold>Methods: </bold>This study was conducted with 138 women who needed pregnancy termination between 13 and 26 gestational weeks, 31 with 3 or more previous cesarean deliveries and 107 with no uterine scars (the controls). Misoprostol was inserted in the vagina every 6 hours until regular contractions or products of conception appeared, a 200-microg tablet for the first 24 hours and 2 tablets thereafter. The outcomes assessed were successful vaginal abortion, hemorrhage requiring blood transfusion, incomplete abortion, and uterine rupture.<bold>Results: </bold>A vaginal abortion occurred in 28 women (90.3%) in the study group and 107 (100%) in the control group (P=0.01). There were no significant differences in the prevalence of the other assessed outcomes.<bold>Conclusion: </bold>Vaginal misoprostol appears to be safe and acceptably effective for second-trimester pregnancy termination in women with 3 or more previous cesarean deliveries.
- Subjects
SECOND trimester of pregnancy; CESAREAN section complications; MISOPROSTOL; VAGINAL medication; ABORTION; GESTATIONAL age; OBSTETRICS surgery complications; HEALTH outcome assessment; ABORTIFACIENTS; CESAREAN section; CLINICAL trials; SCARS; TREATMENT effectiveness; CASE-control method; DISEASE complications; THERAPEUTICS
- Publication
International Journal of Gynecology & Obstetrics, 2010, Vol 110, Issue 1, p50
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2010.02.008