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- Title
Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder.
- Authors
Swerdloff, Ronald S.; YanHe Lue; Liu, Peter Y.; Erkkilä, Krista; Christina Wang
- Abstract
41XXY mouse models share many characteristics of the human 47XXY Klinefelter syndrome (KS). This manuscript discusses the relative role of androgen deficiency and X chromosome genes resulting in the XXY mouse phenotype. The similarities in phenotype between 47XXY men and 41XXY mice suggest that the clinical manifestations in XXY men may be because of gene-dosage effect from genes that escape X inactivation in mouse. The 41XXY mouse is an excellent model for KS.
- Subjects
KLINEFELTER'S syndrome; CHROMOSOMES; GENES; PHENOTYPES; HEREDITY
- Publication
Acta Paediatrica, 2011, Vol 100, Issue 6, p892
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/j.1651-2227.2011.02149.x