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- Title
Hypoxia-induced free iron release in the red cells of newborn infants.
- Authors
Buonocore, G.; Zani, S.; Sargentini, I.; Gioia, D.; Signorini, C.; Bracci, R.
- Abstract
Heparinized blood samples were obtained at birth from 164 newborn infants (101 full term; 63 preterm). Intra-erythrocyte free iron concentration and hypoxanthine plasma levels were determined by high-pressure liquid chromatography. Intra-erythrocyte free iron concentration was higher in preterm than in full term babies (p < 0.0001) and adults (p < 0.0001). Statistically significant correlations were observed between intra-erythrocyte free iron concentration and hypoxanthine levels (r = 0.66; p = 0.0001), pH (r = -0.76; p = 0.0001), base excess (r = -0.79; p = 0.0001), and gestational age (r = -0.44; p = 0.0001) in both infant populations. Multiple regression analysis between intra-erythrocyte free iron concentration in cord blood, as an independent variable, and Apgar score at 1 min, pH, base excess, hypoxanthine values, FiO2 needed for resuscitation immediately after delivery, and gestational age, as dependent variables, identified hypoxanthine levels (p = 0.0003; partial F-test = 15.4) as the best single predictor of intra-erythrocyte free iron concentration. In conclusion, hypoxia induces intra-erythrocyte free iron release, and therefore enhances the risk of oxidative injury due to hydroxyl radical generation.
- Subjects
HYPOXEMIA; ERYTHROCYTES; DIAGNOSIS
- Publication
Acta Paediatrica, 1998, Vol 87, Issue 1, p77
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1080/08035259850157912