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- Title
ParkDB: a Parkinson’s disease gene expression database.
- Authors
Taccioli, Cristian; Maselli, Vincenza; Tegnér, Jesper; Gomez-Cabrero, David; Altobelli, Gioia; Emmett, Warren; Lescai, Francesco; Gustincich, Stefano; Stupka, Elia
- Abstract
Parkinson’s disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species.Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/
- Publication
Database: The Journal of Biological Databases & Curation, 2011, Vol 2011, Issue 7, p1
- ISSN
1758-0463
- Publication type
Article