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- Title
Transient Daratumumab-Induced Refractive Shift in Multidrug-Resistant Multiple Myeloma: Case Report and Literature Review.
- Authors
Troisi, Salvatore; Giudice, Valentina; Troisi, Mario; Morini, Denise; Crudele, Andrea; Cuffa, Bianca; Selleri, Carmine; Serio, Bianca
- Abstract
Daratumumab, an anti-CD38 monoclonal antibody, is worldwide approved for treatment of newly diagnosed and relapsed/refractory multiple myeloma (MM) patients and is available as intravenous or subcutaneous formulations. Intravenous daratumumab is associated with frequent infusion-related reactions, while eye complications, especially refractive shifts, are very rare, with only previously reported cases. Here, we described a rare case of multi-refractory MM who developed transient myopic shift during intravenous daratumumab infusion successfully treated only with cycloplegic collyrium not requiring infusion rate lowering or drug discontinuation. This conservative therapeutic approach allowed termination of induction therapy and autologous hematopoietic stem-cell transplantation resulting in durable complete remission.
- Subjects
LITERATURE reviews; MULTIPLE myeloma; DARATUMUMAB; STEM cell transplantation; MONOCLONAL antibodies; PLASMACYTOMA; ANISOMETROPIA
- Publication
Acta Haematologica, 2023, Vol 146, Issue 5, p424
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000531520