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- Title
An Exploratory Study of the Salivary Immunoglobulin A Responses to 1 Dose of a Norovirus Virus-Like Particle Candidate Vaccine in Healthy Adults.
- Authors
Atmar, Robert L; Cramer, Jakob P; Baehner, Frank; Han, Cong; Borkowski, Astrid; Mendelman, Paul M
- Abstract
As noroviruses are transmitted through the fecal-oral route, we investigated humoral and mucosal (salivary immunoglobulin A [IgA]) immune responses in a phase 2 trial of Takeda's bivalent norovirus virus-like particle (VLP) vaccine candidate in 50 healthy 18- to 49-year-olds. The vaccine had an acceptable tolerability profile and induced rapid, robust humoral immune responses after 1 intramuscular dose of vaccine candidate. Seroresponses were evident 8 days after vaccination as panimmunoglobulin, IgA, and histo-blood group antigen-blocking antibodies against both vaccine GI.1 and GII.4c genotypes. Salivary IgA levels were approximately 1000-fold lower than serum concentrations, and moderately or strongly correlated with the serum IgA titers at all time-points.
- Subjects
IMMUNOGLOBULIN A; NOROVIRUSES; FECAL-oral infection transmission; VIRUS-like particles; IMMUNE response; RESEARCH; VIRAL vaccines; IMMUNOGLOBULINS; IMMUNIZATION; SALIVA; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; ANTIBODY formation; COMPARATIVE studies; BLOOD groups; GENOTYPES; RESEARCH funding; RNA viruses
- Publication
Journal of Infectious Diseases, 2019, Vol 219, Issue 3, p410
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy529