We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application.
- Authors
Xun Yuan; Hua Wu; Na Han; Hanxiao Xu; Qian Chu; Shiying Yu; Yuan Chen; Kongming Wu
- Abstract
Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate that Notch signaling plays an important role in lung cancer initiation and cross-talks with several transcriptional factors to enhance EMT, contributing to the progression of non-small cell lung cancer (NSCLC). Correspondingly, blocking of Notch signaling inhibits NSCLC migration and tumor growth by reversing EMT. Clinical trials have showed promising effect in some cancer patients received treatment with Notch1 inhibitor. This review attempts to provide an overview of the Notch signal in NSCLC: its biological significance and therapeutic application.
- Subjects
CANCER cells; LUNG cancer; TUMOR growth; CLINICAL trials; CANCER cell migration
- Publication
Journal of Hematology & Oncology, 2014, Vol 7, Issue 1, p42
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/s13045-014-0087-z