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- Title
Impaired Bidirectional Synaptic Plasticity and Procedural Memory Formation in Striatum-Specific cAMP Response Element-Binding Protein-Deficient Mice.
- Authors
Pittenger, Christopher; Fasano, Stefania; Mazzocchi-Jones, David; Dunnett, Stephen B.; Kandel, Eric R.; Brambilla, Riccardo
- Abstract
The striatum has a well documented role in procedural learning and memory. However, the synaptic and molecular mechanisms of acquisition and storage ofthisform of memory remain poorly understood.We examined procedural memory and plasticity intransgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. In these transgenic mice, corticostriatal long-term potentiation and depression are abolished, indicating that CREB function is essential for bidirectional long-term synaptic plasticity in this structure. Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory,includingfootshock avoidance learning and “response” learninginthe cross maze. Thesefindings implicatetranscriptional regulation by CREBfamilytranscriptionfactors in striatum-dependent information processing and providethe first clear correlation between procedural learning and memory and synaptic plasticity at the corticostriatal synapse.
- Publication
Journal of Neuroscience, 2006, Vol 26, Issue 10, p2808
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.5406-05.2006