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- Title
Meta-analysis of the association between angiotensin-converting enzyme I/D polymorphism and aortic aneurysm risk.
- Authors
Song, Yan; Miao, Renying; Wang, Hanjie; Qin, Xiaoyu; Zhang, Yonggan; Miao, Chaofeng; Wang, Zifan
- Abstract
<bold>Background: </bold>Angiotensin-converting enzyme (ACE) I/D polymorphism has been indicated to be correlated with aortic aneurysm (AA) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted.<bold>Methods: </bold>Databases including PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.<bold>Results: </bold>Ten studies with 3557 cases and 5231 controls were included in this meta-analysis. The association between ACE I/D genotype and AA risk was significant (OR=1.30; 95%CI, 1.07-1.57; p<0.01; I(2)=68%). When stratified by ethnicity, a significantly elevated risk was observed in Caucasians (OR=1.31; 95%CI, 1.07-1.61; p<0.01; I(2)=71%). In the abdominal AA subgroup, a significantly increased risk was observed (OR=1.29; 95%CI, 1.03-1.62; p=0.02; I(2)=73%). However, ACE I/D polymorphism was not associated with thoracic AA risk (OR=1.33; 95%CI, 0.85-2.07; p=0.21; I(2)=52%). Subgroup analysis on blood pressure status showed that an increased risk was found in hypertensive patients (OR=1.52; 95%CI, 1.02-2.26; p=0.04; I(2)=0%) but not in normotensive subjects (OR=1.46; 95%CI, 0.72-2.96; p=0.30; I(2)=25%).<bold>Conclusions: </bold>In conclusion, this meta-analysis suggested that ACE I/D polymorphism is a risk factor for AA.
- Subjects
ANGIOTENSIN converting enzyme; AORTIC aneurysms; COMPARATIVE studies; DISEASE susceptibility; GENETIC polymorphisms; GENETIC techniques; RESEARCH methodology; MEDICAL cooperation; META-analysis; GENETIC mutation; RESEARCH; EVALUATION research; ODDS ratio
- Publication
Journal of the Renin-Angiotensin-Aldosterone System, 2015, Vol 16, Issue 4, p1125
- ISSN
1470-3203
- Publication type
journal article
- DOI
10.1177/1470320314545557