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- Title
Concentration and secretion of gastric somatostatin in streptozotocin-diabetic rats.
- Authors
Chiba, Tsutomu; Kadowaki, Seizo; Taminato, Tomohiko; Abe, Hiromi; Chihara, Kazuo; Matsukura, Shigeru; Goto, Yasuo; Seino, Yutaka; Fujita, Takuo; Chiba, T; Kadowaki, S; Taminato, T; Abe, H; Chihara, K; Matsukura, S; Goto, Y; Seino, Y; Fujita, T
- Abstract
Both the release and the content of gastric somatostatin were investigated in streptozotocin-diabetic rats. Fundic and antral somatostatin contents were both increased in streptozotocin-diabetic rats compared with control animals. Basal somatostatin levels in the perfusates of streptozotocin-treated animals were not significantly different from those of the control animals. However, the peak values of somatostatin release induced by 5 x 10(-9) M glucagon in the diabetic animals were significantly higher than those of the controls. These results lead us to conclude that a hyperfunctioning state of the gastric D-Cells exists in hypoinsulinemic diabetes.
- Publication
Diabetes, 1981, Vol 30, Issue 3, p188
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.30.3.188