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- Title
GOLPH2 expression in renal cell cancer.
- Authors
Fritzsche FR; Riener MO; Dietel M; Moch H; Jung K; Kristiansen G; Fritzsche, Florian Rudolf; Riener, Mark-Oliver; Dietel, Manfred; Moch, Holger; Jung, Klaus; Kristiansen, Glen
- Abstract
<bold>Background: </bold>Renal cell carcinomas (RCC) are among the most common and most lethal genitourinary malignancies. GOLPH2 (golgi phosphoprotein 2, GOLM1) has recently been proposed as a biomarker for hepatocellular and prostate cancer. In this study we analysed the expression patterns and the prognostic and diagnostic value of GOLPH2 in RCC.<bold>Methods: </bold>GOLPH2 protein expression was analysed by immunohistochemistry in 104 clinically well characterized RCC cases in comparison with matched normal kidney tissue and in association with clinico-pathological parameters. Statistical analyses including Kaplan Meier analyses were performed with SPSS version 15.0.<bold>Results: </bold>GOLPH2 was highly expressed in normal renal tubules and in almost half of RCC with a statistically significant predominance in the papillary and chromophobe histological subtypes. No other associations with clinico-pathological parameters were detectable. The Kaplan-Meier curves showed a weak trend for unfavourable prognosis of tumours with high GOLPH2 expression, but failed significance.<bold>Conclusion: </bold>GOLPH2 protein is expressed in normal renal tissue (especially in distal tubular epithelia) and is down-regulated in the majority of clear cell RCC. In papillary and chromophobe RCC GOLPH2 expression is consistently present. In contrast to its diagnostic value in hepatocellular and prostatic carcinomas, a prognostic or diagnostic value of GOLPH2 in RCC appears to be unlikely.
- Publication
BMC Urology, 2008, Vol 8, p15
- ISSN
1471-2490
- Publication type
journal article
- DOI
10.1186/1471-2490-8-15