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- Title
Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer.
- Authors
Oh, Sung Yong; Kwon, Hyuk-Chan; Kim, Sung-Hyun; Jang, Jin Seok; Kim, Min Chan; Kim, Kyeong Hee; Han, Jin-Yeong; Kim, Chung Ock; Kim, Sujin; Jeong, Jin-sook; Kim, Hyo-Jin
- Abstract
Background: Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α(HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mechanisms inherent to tumor progression. In this work, we have investigated the clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF (sVEGF) level in gastric cancer. We immunohistochemically assessed the HIF-1α, p53, and VEGF expression patterns in 114 specimens of gastric cancer. Additionally, we determined the levels of preoperative serum VEGF (sVEGF). Results: The positive rates of p53 and HIF-1α (diffuse, deep, intravascular pattern) were 38.6% and 15.8%, respectively. The VEGF overexpression rate was 57.9%. p53 and HIF-1α were correlated positively with the depth of invasion (P = 0.015, P = 0.001, respectively). Preoperative sVEGF and p53 levels were correlated significantly with lymph node involvement (P = 0.010, P = 0.040, respectively). VEGF overexpression was more frequently observed in the old age group (= 60 years old) and the intestinal type (P = 0.013, P = 0.014, respectively). However, correlations between preoperative sVEGF level and tissue HIF-1α, VEGF, and p53 were not observed. The median follow-up duration after operation was 24.5 months. HIF-1α was observed to be a poor prognostic factor of disease recurrence or progression (P = 0.002). Conclusion: p53, HIF-1α and preoperative sVEGF might be markers of depth of invasion or lymph node involvement. HIF-1α expression was a poor prognostic factor of disease recurrence or progression in patients with gastric cancers.
- Subjects
HYPOXEMIA; P53 antioncogene; VASCULAR endothelial growth factors; TUMOR growth; STOMACH cancer; NEOVASCULARIZATION
- Publication
BMC Cancer, 2008, Vol 8, p1
- ISSN
1471-2407
- Publication type
Article
- DOI
10.1186/1471-2407-8-123